The New York Mets scored runs in the ninth and tenth innings Wednesday night to notch a come-from-behind 5-4 victory over the Los Angeles Angels.

After David Wright spoiled Angels’ closer Francisco Rodriguez’s save opportunity with a two-out RBI single in the ninth, Damion Easley homered in the 10th to give new manager Jerry Manuel his first Mets victory.

Starter Oliver Perez, who pitched a solid game during our visit to Shea Friday night, threw three scoreless innings before yielding four runs in the fourth and fifth. He lost his no-hit bid in the third inning when Chone Figgins singled to right, bumping our NoNoHitters.com count to 7,391 without a Mets no hitter.

Day One of the Mets’ Jerry Manuel era ended in a 6-1 loss.

The apparently tired New York Mets committed three errors and managed just six hits, and ace starter Johan Santana yielded five runs (four of them earned), a pair of walks and eight hits in six innings of work to take the loss to the Los Angeles Angels of Anaheim and other various surrounding California metro areas.

Perhaps that’s what happens when a team makes a managerial change at 3:15 a.m. EDT. That doesn’t exactly help rest the squad after a playing a night game after a three hour flight.

Willie Randolph’s firing also did little to change the Mets’ no hit fortunes. Santana gave up a first inning single to Maicer Izturis to boost the NoNoHitters.com count to 7,390 games without a Mets no hitter.

For the 900th time in franchise history, a potential New York Mets no hitter has been broken up by the first at-bat.

Chone Figgins doubled to left off Mike Pelfrey Monday night to increase the NoNoHitters.com count to 7,389 New York Mets games without a single no-no. It’s the 900th time that has happened on the first at bat, and the 675th time it has occurred with a single. (Check out our No hitters killed by first at bat for more details.)

This is happening way to often this season. Over the Mets’ previous 46 seasons, there have been an average of just over 19 no hitters broken up on the first at-bat. So far in 2008 (and we’re not even close to the All Star break yet) there have been 22! And Pelfrey has had six of them:

• May 3, 2008: In Arizona, Mike Pelfrey gives up a leadoff single to the Diamondbacks’ Chris Young.
• May 10, 2008 (Game 2 of a day-night doubleheader): In New York, Mike Pelfrey gave up a leadoff double to the Cincinnati Reds’ Ryan Freel.
• May 31, 2008: In New York, Mike Pelfrey gives up a leadoff single to the Los Angeles Dodgers’ Juan Pierre
• June 5, 2008: In San Diego, Mike Pelfrey gives up a leadoff single to the Padres’ Jody Gerut
• June 12, 2008: In New York, Mike Pelfrey gives up a leadoff single to the Arizona Diamondbacks’ Chris Young
• June 16, 2008: In Anaheim, Mike Pelfrey gives up a leadoff single to the Los Angeles Angels’ Chone Figgins

Of course, Pelfrey also went the deepest this season without giving up a hit, throwing six innings of no-hit ball against the Washington Nationals on May 15.

The Mets won 9-6, but it was not enough to save the job of Manager Willie Randolph, who was let go a couple hours after the game finished.