The Seattle Mariners, a 1977 American League expansion franchise, has been no-hit seven times, with both the first and fourth thrown by the Angels franchise.
Here are the no-hitters against the Mariners:
| 1 | Mark Langston (7 inn.) Mike Witt (2 inn.) |
|---|---|
| California Angels (AL) | |
| Wednesday, April 11, 1990 California Angels 1, Seattle Mariners 0 Anaheim Stadium (Anaheim) (Witt participates in a multiple pitcher no-hitter after throwing his own on Sept. 30, 1984.) |
|
| 2 | Dwight “Doc” Gooden |
| New York Yankees (AL) | |
| Tuesday, May 14, 1996 New York Yankees 2, Seattle Mariners 0 Yankee Stadium (New York) |
|
| 3 | Philip Humber |
| Chicago White Sox (AL) | |
 Saturday, April 21, 2012Chicago White Sox 4, Seattle Mariners 0 Safeco Field (Seattle) (Perfect game) |
|
| 4 | Taylor Cole (2 inn.) Félix Peña (7 inn.) |
| Los Angeles Angels (AL) | |
| Friday July 12, 2019 Los Angeles Angels 13, Seattle Mariners 0 Angel Stadium of Anaheim (Anaheim) Angels toss a combined no-hitter on a night honoring late pitcher Tyler Skaggs with all teammates wearing his No. 45. |
|
| 5 | Aaron Sanchez (6 inn.) Will Harris (1 inn.) Joe Biagini (1 inn.) Chris Devenski (1 inn.) |
| Houston Astros (AL) | |
| Saturday, August 3, 2019 Houston Astros 9, Seattle Mariners 0 Minute Maid Park (Houston) |
|
| 6 | John Means |
| Baltimore Orioles (AL) | |
| Wednesday, May 5, 2021 Baltimore Orioles 6, Seattle Mariners 0 T-Mobile Park (Seattle) Means throws the first MLB no-hitter in which the only baserunner reached on a dropped third strike. |
|
| 7 | Spencer Turnbull |
| Detroit Tigers (AL) | |
| Tuesday, May 18, 2021 Detroit Tigers 5, Seattle Mariners 0 T-Mobile Park (Seattle) |