The Boston Red Sox, an American League charter franchise first known simply as the Americans, have been no-hit 12 times since 1901. The Yankees no-hit the Red Sox three times, and the Senators and White Sox each did it twice.
Here are the no-hitters vs. the Red Sox:
| 1 | Bob "Dusty" Rhoads |
|---|---|
| Cleveland Naps (AL) | |
| Friday, September 18, 1908 Cleveland Naps 2, Boston Red Sox 1 League Park (Cleveland) |
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| 2 | Ed Walsh |
| Chicago White Sox (AL) | |
| Sunday, August 27, 1911 Chicago White Sox 5, Boston Red Sox 0 Comiskey Park (Chicago) |
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| 3 | George Mogridge |
| New York Yankees (AL) | |
| Tuesday, April 24, 1917 New York Yankees 2, Boston Red Sox 1 Fenway Park (Boston) |
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| 4 | Walter Johnson |
| Washington Senators (AL) | |
| Thursday, July 1, 1920 Washington Senators 1, Boston Red Sox 0 Fenway Park (Boston) |
|
| 5 | Ted Lyons |
| Chicago White Sox (AL) | |
| Saturday, August 21, 1926 Chicago White Sox 6, Boston Red Sox 0 Fenway Park (Boston) |
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| 6 | Bobby Burke |
| Washington Senators (AL) | |
| Saturday, August 8, 1931 Washington Senators 5, Boston Red Sox 0 Griffith Stadium (Washington, D.C.) |
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| 7 | Allie Reynolds |
| New York Yankees (AL) | |
| Friday, September 28, 1951 (First game of doubleheader) New York Yankees 8, Boston Red Sox 0 Yankee Stadium (New York) (His second of two no-hitters) |
|
| 8 | Jim Bunning |
| Detroit Tigers (AL) | |
| Sunday, July 20, 1958 (First game of doubleheader) Detroit Tigers 3, Boston Red Sox 0 Fenway Park (Boston) (His first of two no-hitters) |
|
| 9 | Tom Phoebus |
| Baltimore Orioles (AL) | |
| Saturday, April 27, 1968 Baltimore Orioles 6, Boston Red Sox 0 Memorial Stadium (Baltimore) |
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| 10 | Dave Righetti |
| New York Yankees (AL) | |
| Monday, July 4, 1983 New York Yankees 4, Boston Red Sox 0 Yankee Stadium (New York) |
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| 11 | Chris Bosio |
| Seattle Mariners (AL) | |
| Thursday, April 22, 1993 Seattle Mariners 7, Boston Red Sox 0 Kingdome (Seattle) |
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| 12 | Sean Manaea |
| Oakland Athletics (AL) | |
| Saturday, April 21, 2018 Oakland Athletics 3, Boston Red Sox 0 Oakland–Alameda County Coliseum (Oakland) |