The Houston Astros, a circa-1962 National League team originally known as the Colt .45s, have been no-hit five times over the club’s history.
Here are the no-hitters against the Astros:
| 1 | Juan Marichal |
|---|---|
| San Francisco Giants (NL) | |
| Saturday, June 15, 1963 San Francisco Giants 1, Houston Colt .45s 0 Candlestick Park (San Francisco) |
|
| 2 | Jim Maloney |
| Cincinnati Reds (NL) | |
| Wednesday, April 30, 1969 Cincinnati Reds 10, Houston Astros 0 Crosley Field (Cincinnati) (His second of two no-hitters) |
|
| 3 | Francisco Cordova (9 inn.) Ricardo Rincon (1 inn.) |
| Pittsburgh Pirates (NL) | |
| Saturday, July 12, 1997 Pittsburgh Pirates 3, Houston Astros 0 (10 innings) Three Rivers Stadium (Pittsburgh) |
|
| 4 | Carlos Zambrano |
| Chicago Cubs (NL) | |
| Sunday, September 14, 2008 Chicago Cubs 5, Houston Astros 0 Miller Park (Milwaukee) (Played in Milwaukee’s Miller Park because of damage in the Houston area from Hurricane Ike, the was the first Major League no-hitter played at a neutral site.) |
|
| 5 | Matt Cain |
| San Francisco Giants (NL) | |
 Wednesday, June 13, 2012San Francisco Giants 10, Houston Astros 0 AT&T Park (San Francisco) (Perfect game) |